Dr. Kenneth W. Funk

M.Sc in Organic Chemistry, PhD in Organic Chemistry, Logos Research Associate

Biography:

Dr. Kenneth Funk attended Moody Bible Institute, graduated from Houghton College as a chemistry major, zoology minor and Case-Western Reserve University with both masters and doctorate degrees in organic chemistry specializing in amino acid and peptide chemistry in the laboratory of world-renowned Professor Miklos Bodanzsky. His main process development activities at Abbott included leading a section of chemists developing a process for and manufacturing Lupron, TAP Pharmaceutical's billion-dollar nonapeptide drug for the treatment of prostate cancer, endometriosis, uterine fibroids, precocious puberty and in-vitro fertilization. During that time, he had twelve publications, three patents, nine patent disclosures and a book chapter.

 

 

Selected Papers & Books:

  • “LHRH Agonists” Funk KW; Greer J; Adjei AL, (In) Intergration of Pharmaceutical Discovery and Development - Case Histories, Volume 11; Borshardt RT; Freidinger RM; Sawyer TK; Smith PL, eds., Plenum Publishers, 1998, p 151-182.

  • A large scale synthesis of IgE Pentapeptide, Tolle JC; Heinrichsmeyer DN; Miller RB; Gifford WZ; Lundell EO; Funk KW, (In):Peptides 1992, C.H. Schneider and A.A. Eberle, eds., ESCOM Science Publishers B.V., 1992, pp. 52-53

  • Large-scale synthesis and biophysical activity of lung surfactant peptide, SP-B(53-78) diACM, Lundell EO; Chang JL; Dhaon MK; Cozine MG; Funk KW; Absolom D; Baxter C; Gupta S, (In):Peptides 1992, C.H. Schneider and A.A. Eberle, eds., ESCOM Science Publishers B.V., 1992, pp. 427-428

  • Kilograms of Peptides, Tolle JC; Funk KW, ChemSpec USA 1990 Symposium

  • Large scale preparation of renin inhibitor A-64662., Miller RB; Tolle JC; Langridge D; Tien J-H; Funk KW., (In):Peptides 1990, Proceedings of the Twenty-First European Peptide Symposium; E. Giralt and D. Andreu, eds., Leiden, ESCOM Science Publishers B.V., 1991, pp. 115-117.

  • Use of Azides as Intermediates in Large-Scale Peptide Synthesis, Miller RB; Tolle JC; Funk KW, (In):Peptides, Proceedings of the Eleventh American Peptide Symposium,  J.E. Rivier and G. R. Marshall, eds., ESCOM Science Publishers B.V., 1990, pp. 1007-1009

  • Novel Process for the Production of LH-RH Using CTH And Preparative HPLC, Tien J-H; Funk KS; Jamrog C; Carney RE, (In):Peptide Chemistry 1987, T. Shiba and S. Sakakibara, eds., p. 375-379.

  • A Reexamination of the Conformation of Secretin in Water, Bodanszky M; Fink ML; Funk KW; Said SI,       Clin. Endocrin. 5, Suppl., 195-200 (1976).

  • Rigid Active Esters in Peptide Synthesis, Bodanszky M; Fink ML; Funk KW; Kondo M; Lin CY; Bodanszky A.,  J. Amer. Chem. Soc. 96, 2234 (1974).

  • Experiments with Active Esters in Solid Phase Peptide Synthesis, Bodanszky M; Bath RJ; Chang A; Fink ML; Funk KW; Greenwald SM; Klausner YS, (In):Proceedings of the Third American Peptide Symposium (1973), p. 203.

  • o-Nitrophenyl Ester in Solid Phase Peptide Synthesis, Bodanszky M and K.W. Funk,  J. Org. Chem. 38, 1296 (1973).

  • o-Nitrophenyl Esters of t-Butyloxycarbonylamino Acids and Their Application in the Stepwise Synthesis of Peptide Chains by a New Technique, Bodanszky M; Funk KW; Fink ML,  J. Org. Chem. 38, 3565 (1973).

PATENTS:

  • Pentapeptide Synthesis, Tolle JC; Gifford WZ; Funk KW, U.S. Patent No. 5,212,287

  • Process for Intermediates for the Synthesis of LHRH Antagonists, Funk KW; Lundell EO; Miller RB; Chang JL; Kishore V; Napier JJ; Staeger M, U.S. Patent Number 5,710,246

  • Process and Intermediates for the Synthesis of LHRH Antagonists, Funk KW; Lundell EO; Miller RB; Chang JL; Kishore V; Napier JJ; Staeger M, U.S. Patent Number 5,710,247

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